| 1 | BUT | Jenson Alexander Lyons Button | GB |  | Vodafone McLaren Mercedes | McLaren MP4-25 | Mercedes FO108X | Bridgestone |
| 2 | HAM | Lewis Carl Davidson Hamilton | GB | |
| T | PAF | Gary Paffett | GB | |
| 3 | MSC | Michael Schumacher | D |  | Mercedes GP Petronas F1 Team | Mercedes MGP W01 | Mercedes FO108X | Bridgestone |
| 4 | ROS | Nico Erik Rosberg | D | |
| T | HEI | Nick Lars Heidfeld | D | |
| 5 | VET | Sebastian Vettel | D | | Red Bull Racing | Red Bull RB6 'Luscious Liz'
Red Bull RB6 'Randy Mandy' | Renault RS27 | Bridgestone |
| 6 | WEB | Mark Alan Webber | AUS |  | Red Bull RB6 |
| T | HAR | Brendon Hartley | NZ |  |
| T | RIC | Daniel Ricciardo | AUS | |
| 7 | MAS | Felipe Massa | BR |  | Scuderia Ferrari Marlboro | Ferrari F10 | Ferrari 056 | Bridgestone |
| 8 | ALO | Fernando Alonso Díaz | E |  |
| T | BAD | Luca Badoer | I |  |
| T | FIS | Giancarlo Fisichella | I | |
| T | GEN | Marc Gené Guerrero | E | |
| 9 | BAR | Rubens Gonçalves Barrichello | BR | | AT&T Williams | Williams FW32 | Cosworth CA2010 | Bridgestone |
| 10 | HUL | Nicolas Hülkenberg | D | |
| T | BOT | Valtteri Bottas | FIN |  |
| 11 | KUB | Robert Jósef Kubica | PL |  | Renault F1 Team | Renault R30 | Renault RS27 | Bridgestone |
| 12 | PET | Vitaly Aleksandrovich Petrov | RUS |  |
| T | DAM | Jérôme D'Ambrosio | B |  |
| T | | Ho-Pin Tung | CN |  |
| 14 | SUT | Adrian Sutil | D | | Force India F1 Team | Force India VJM03 | Mercedes FO108X | Bridgestone |
| 15 | LIU | Vitantonio Liuzzi | I | |
| 14,15 | DIR | Paul Di Resta | GB | |
| 16 | BUE | Sébastien Buemi | CH |  | Scuderia Toro Rosso | Toro Rosso STR5 | Ferrari 056 | Bridgestone |
| 17 | ALG | Jaime Alguersuari Escudero | E | |
| T | HAR | Brendon Hartley | NZ | |
| T | RIC | Daniel Ricciardo | AUS | |
| 18 | TRU | Jarno Trulli | I | | Lotus Racing | Lotus T127 | Cosworth CA2010 | Bridgestone |
| 19 | KOV | Heikki Johannes Kovalainen | FIN | |
| 18,19 | FAU | Mohamed Fairuz Fauzy | MAL |  |
| 20 | CHA | Karun Chandhok | IND |  | HRT F1 Team | HRT F110 | Cosworth CA2010 | Bridgestone |
| 20 | KLI | Christian Klien | A |  |
| 21 | SEN | Bruno Senna Lalli | BR | |
| 20,21 | YAM | Sakon Yamamoto | J |  |
| 22 | DLR | Pedro Martinez de la Rosa | E | | BMW Sauber F1 Team | BMW Sauber C29 | Ferrari 056 | Bridgestone |
| 22 | HEI | Nick Lars Heidfeld | D | |
| 23 | KOB | Kamui Kobayashi | J | |
| R | GUT | Esteban Manuel Gutiérrez Gutiérrez | MEX |  |
| 24 | GLO | Timo Glock | D | | Virgin Racing | Virgin VR-01 | Cosworth CA2010 | Bridgestone |
| 25 | DIG | Lucas Tucci Di Grassi | BR | |
| 25 | DAM | Jérôme D'Ambrosio | B | |
| T | | Álvaro Parente | P |  |
| T | RAZ | Luiz Tadeu Razia Filho | BR | |
| legend |
All engine specs in 2010 are 2.4 V8 @90°
All cars may use KERS - Kinetic Energy Recovery System - in 2010, but the FOTA agreed not to use it. |
| story |
- In mid of 2009 BMW decided to quit the sport end of 2009.
- To fill up the grid to 26 cars, four new private teams are entering in 2010, all of them using the new Cosworth engines:
Lotus F1 Racing, Campos Meta 1, US F1 Team and Virgin Racing.
- End of 2009 Toyota also decided to quit the sport, so again there are 'only' 12 teams on the grid.
- Because Toyota left Formula One, Williams has to chose a new engine suplier and decided for the new Cosworth engines.
- In November 2009 Mercedes baught a stake of 75.1% in Brawn GP and renamed it to Mercedes Grand Prix.
- Peter Sauber has bought out the shares of BMW with help of new investors.
- Sauber has been granted the 13th team entry.
- Campos Meta 1 has changed it's name to Hispania Racing F1 Team two weeks before the season opener after the team president Jose Ramon Carabante took over the team from former owner Adrian Campos.
- 14. Sept. 2010: Nick Heidfeld will replace Pedro de la Rosa at the Sauber team for the last five races in 2010
- Driver transfer 2009 --> 2010:
- Button switched from Brawn GP to McLaren, so McLaren inherited start nr. 1 in 2010.
- Rosberg switched from Williams to the new Mercedes Grand Prix team.
- Alonso switched from Renault to Ferrari.
- Barrichello switched from Brawn GP to Williams.
- Kubica switched from BMW Sauber to Renault.
- Glock switched from Toyota to the new Virgin Racing team.
- Raikkonen decided to leave Formula One for a one-year-off to eventually probe rallying.
- Fisichella will remain at Ferrari as reserve and test driver
- Trulli switched from Toyota to the new Lotus F1 Team.
- Kovalainen switched from McLaren to the new Lotus F1 Team.
- After an impressive showing in the last two races 2009 for Toyota as replacement for the injured Timo Glock, Kamui Kobayashi signed for one year at Sauber Racing.
- Michael Schumacher signed a three year deal with the new Mercedes Grand Prix team, so now we will have a full german Silberpfeil team.
- Pedro de la Rosa is signed along Kobayashi as second driver at Sauber Racing.
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